Study Design Types
Systematic Reviews usually focuses on a specific clinical question and conducts an extensive literature search to identify studies with sound methodology. The studies are reviewed, assessed, and the results summarized according to the predetermined criteria of the review question.
A Meta-analysis takes a systematic review one step further by combining all the results using accepted statistical methodology.
A study that shows the efficacy of a diagnostic test is called a prospective, blind comparison to a gold standard study. This is a controlled trial that looks at patients with varying degrees of an illness and administers both diagnostic tests -- the test under investigation and the "gold standard" test -- to all of the patients in the study.
Cohort studies identify a large population who already has a specific exposure or treatment, follows them over time (prospective), and compares outcomes with another group that has not been affected by the exposure or treatment being studied. Cohort studies are observational and not as reliable as randomized controlled studies, since the two groups may differ in ways other than in the variable under study.
Case control studies are studies in which patients who already have a specific condition or outcome are compared with people who do not. Researchers look back in time (retrospective) to identify possible exposures. They often rely on medical records and patient recall for data collection. These types of studies are often less reliable than randomized controlled trials and cohort studies because showing a statistical relationship does not mean than one factor necessarily caused the other.
Case series and Case reports consist of collections of reports on the treatment of individual patients or a report on a single patient. Because they are reports of cases and use no control groups with which to compare outcomes, they have no statistical validity.
From: Duke University Medical Center Library, December 2005 (last retrieved January 20, 2009)
http://www.mclibrary.duke.edu/subject/ebm/searching/ebmresources.pdf
Search strategies will vary, depending on the database you use. Click the "Info" icon for suggested search strategies for a database.
M - Methodology
O - Oriented
L - Locators for
E - Evidence-based
S - Searching
The type of question you want to answer will determine the methodology you will need to try and find. Consider using the linked planning sheet created by Leonard E. Gibbs from his book Evidence-based practice for the helping professions: A practical guide with integrated multimedia.